Research

COVID-19 Research

Title :

Targeting the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 for the development of inhibitors

Area of research :

COVID-19 Research, Life Sciences & Biotechnology

Focus area :

Therapeutics for COVID-19

Principal Investigator :

Prof Benu Brata Das, Indian Association for the Cultivation of Science (IACS), Kolkata

Timeline Start Year :

2020

Contact info :

Details

Executive Summary :

The goal of this proposal is to devise potent small molecule inhibitors against SARS-CoV-2 RNA-dependant RNA polymerase (RdRp) based on the quinoline scaffold for COVID-19 treatment.

Outcome/Output:

Quinolines-based heterocyclic molecules composed of fused benzene and pyridine rings was synthesised, which have shown to display strong antiviral properties against various viral pathogens. Finally, using in silico tools for drug discovery and molecular modeling, the docking score, free binding energies and key interactions between the ligands and the RdRp in comparision with Remdesivir were evidenced.

Organizations involved