Life Sciences & Biotechnology
Title : | Role of pseudouridine modification of the mRNAs of mitochondrial respiratory complex proteins in RNA metabolism and mitochondrial metabolic disorders |
Area of Research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. santosh Kumar, National Institute Of Technology (NIT) Rourkela, Odisha |
Contact info : | santy.poo@gmail.com |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Total Budget (INR): | 52,45,834 |
Details
Executive Summary : | Pseudouridine (ϰ) is a common nucleotide modification found in cellular RNA and mitochondrially encoded mRNAs. It is linked to various diseases such as cancer, MLAsA, MIDD, HIV, X-linked dyskeratosis congenita, and hoyeraal-hreidarsson syndrome. Pseudouridine is found in urine metabolites of cancer patients and saliva of oral squamous cell carcinoma patients. It plays a significant role in cellular activities like translation, RNA stability, and RNA processing. The study aims to identify RBPs binding at the ϰ position and the functions of cells regulated by these interactions. The results will reveal the complex interplay of posttranscriptional RNA modifications with cellular functions and associated human diseases. |
Equipments : | Nanodrop
Thermomix
Gradient PCR
Workstation |
Organizations involved