Life Sciences & Biotechnology
Title : | Profiling and evaluation of prebiotic potential of oligosaccharides present in anti-arthritic medicinal plant - based functional foods using CFA induced arthritic animal model and to explore the association of gut microbiome and arthritis |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Prof. T Sivasudha, Bharathidasan University, Tamil Nadu |
Timeline Start Year : | 2022 |
Timeline End Year : | 2025 |
Contact info : | sudacoli@yahoo.com |
Equipments : | High end Microscope |
Details
Executive Summary : | The study focuses on health promotion through dietary modulation of the intestinational microflora through the consumption of functional foods. Prebiotics are considered a superior way of managing health issues through directed inflection of gut microbiota. Prebiotics are carbohydrate compounds, primarily oligosaccharides, known to deter digestion in the human small intestine and reach the colon where they are fermented by the gut microflora. Functional foods provide specific health benefits beyond their nutritional format. Plants have been used as food and medicine since ancient times, and their phytochemicals, including alkaloids, phenols, flavonoids, terpenes, antioxidants, and polyunsaturated fatty acids, are considered functional foods. According to the World Health Organization (WHO), 0.3-1% of the world population is affected by rheumatoid arthritis (RA), with females being three times more prone to the disease. Prebiotics can restore gut microbiota diversity and safeguard a healthy homeostatic state of microbiome-host relationship, which is crucial for stopping or suspending the onset of autoimmunity and tumbling the progression and outbreak of autoimmune diseases. The study evaluated the anti-arthritic activity of four medicinal plants, Cissus quadrangularis, Cardiospermum halicacabum, Pisoina alba, and Percularia daemia, using a CFA-induced arthritic animal model. The aim is to study the role of prebiotic oligosaccharides in preventing arthritis through regulation of gut mucrobiome homeostasis. |
Co-PI: | Dr. Achiraman Shanmugam, Bharathidasan University, Tamil Nadu-620024 |
Total Budget (INR): | 25,23,400 |
Organizations involved