Life Sciences & Biotechnology

Title :

Preclinical development of small molecules promoting hair regeneration and studying mechanism of hair regeneration

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Hair regeneration

Principal Investigator :

Dr Mohd Jamal Dar, Scientist, CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu

Timeline Start Year :


Timeline End Year :


Contact info :


Executive Summary :

Objective: Medicinal chemistry and in-vitro activity analysis of hits previously identified from IIIM Compound Repository as JAK-STAT and GSK-3-beta inhibitors for the lead development. Medicinal chemistry and in-vitro activity analysis of scaffolds based on pyrrolo¬pyrimidine and pyrazolo-pyrimidine scaffolds. Establishing and studying efficacy of identified leads using in vivo mouse models of hair regeneration for validation. Establishing and optimization of in vitro conditions for the proliferation and subsequent differentiation of hair follicle stem cells (HFSCs) and elucidating molecular mechanism regulating HFSC differentiation.

Organizations involved