Research
Title : | Identification and characterization of small molecules to block PD1/PDL1 pathway in immunotherapy |
Area of Research : | Medical Sciences |
Focus Area : | Cancer Immunotherapy, Drug Discovery |
Principal Investigator : | Dr. Amit Awasthi, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana; Dr. Pranjal Gogoi, CSIR- North East Institute of Science and Technology (NEIST), Jorhat, Assam |
Co-PI: | Dr. Shailendra Asthana, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana |
Contact info : | aawasthi@thsti.res.in,pranjalgogoi@neist.res.in; sasthana@thsti.res.in |
Timeline Start Year : | 2022 |
Timeline End Year : | 2025 |
Total Budget (INR): | 63,.3,552 |
Details
Executive Summary : | Blocking the interactions between programmed cell death protein 1 (PD-1) and its ligand, PD-L1, has emerged as a promising immunotherapy for treating cancer. Cancer immunotherapy harnesses the immune system to battle tumors: it directly targets the immune system rather than the tumors [3,4]. An immune checkpoint is a molecule in the immune system that either enhances (co-stimulatory molecules) or inhibits a signal [5,6]. The blockade of immune checkpoints can activate therapeutic antitumor immunity. There are currently several mAbs approved for the treatment of cancers as an effective target for cancer immunotherapy and clinical results have shown that anti-PD-1 therapy is superior to chemotherapy in the treatment of metastatic melanoma. There are some disadvantages to Ab-mediated immunotherapy too, like production cost, stability, and immunogenicity; therefore, low-molecular weight immune checkpoint inhibitors of PD-1/PD-L1 have become attractive targets in the drug discovery. |
Equipments : | NA |
Achievements : | Indazole and triazole-based small molecules were shortlisted for synthesis. Compounds identified by targeting the binding site were evaluated in in-vitro assays. After completion of analysis Indian patent will file.All the synthesized compounds were characterized using NMR and HRMS analysis. Additionally, the purity of our synthesized compounds was evaluated using HPLC. Photophysical properties, including absorption, emission, and quantum yields, were also evaluated. |
Outcome/Output: | 1 |
Organizations involved
Implementing Agency : | Translational Health Science and Technology Institute (THSTI)Faridabad, Haryana Funding Agency :Department of Science and Technology (DBT) | Source: E-promis and Information received by Investigator | |