Research
Title : | Evaluating Medicinal Plants from Northeast India in Mitigating Ailments Associated with Metabolic Dysregulations |
Area of Research : | Agricultural Sciences |
Focus Area : | Medicinal Plants, Phytopharmaceuticals |
Principal Investigator : | "Dr. Soumen Basak, National Institute of Immunology (NII), New Delhi; Prof. Pardeep Bharadwaj, Institute of Bioresources and Sustainable Development (IBSD), Imphal, Manipur" |
Co-PI: | Dr. Devram Ghorpade, National Institute of Immunology (NII), New Delhi; Dr. Debasisa Mohanty, National Institute of Immunology (NII), New Delhi; Dr. Arnab Mukhopadhyay, National Institute of Immunology (NII), New Delhi; Dr. G. Aneeshkumar Arimbasseri, National Institute of Immunology (NII), New Delhi; Dr. Devram Ghorpade, National Institute of Immunology (NII), New Delhi; Dr. Nanaocha Sharma, Institute of Bioresources and Sustainable Development (IBSD), Imphal, Manipur Dr. Pardeep Bhardwaj, Institute of Bioresources and Sustainable Development (IBSD), Imphal, Manipur Dr. Rajashekar Y, Institute of Bioresources and Sustainable Development (IBSD), Imphal, Manipur Dr. S. Indira Devi, |
Contact info : | sobasak@nii.ac.in; pardeep2128@gmail.com; pushkar@nii.ac.in; deb@nii.ac.in; arnab@nii.ac.in; aneesh@nii.ac.in; dev@nii.ac.in; sharma.nanaocha@gmail.com; pardeep2128@gmail.com; yrajashekar.ibsd@nic.in; sidevi1@yahoo.co.in |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Total Budget (INR): | 47,9.,26,216 |
Details
Executive Summary : | This collaborative program is one-of-a-kind attempt for evaluating medicinal properties of northeast plants simultaneously in nematodes and in mice, concurrently probing multiple pathological manifestations of metabolic derangements, including inflammatory colitis, muscle wasting, and aging. We hope that the proposed program will direct northeast-based plant-derived substance in lessening metabolic deregulations and associated ailments, while offering important mechanistic insights on their mode of action. In particular, it will be interesting to note if certain plant formulations more efficaciously intervene at specific ailments associated with metabolic dysregulations than others. In the end, we feel that the proposed experimental pipeline will also be beneficial for implementing a program of an even larger scale to explore a wider spectrum of traditional Indian medicines in the future. |
Equipments : | Flow Cytometer |
Achievements : | Plant species namely Dillenia indica L. (Imphal East, Manipur), Garcinia xanthochymus Hook.f. ex T.Anderson (Lamshang, Manipur), Paris polyphylla Sm. (Makhel, Manipur), Swertia chirayita (Roxb.) H.Karst. (East Khasi Hills, Meghalaya), and Allium hookeri Thwaites (Thoubal, Manipur) were collected and authenticated by the Botanist, IBSD, Imphal, Manipur. The collected plant samples from D. Indica (Fruit), G. Xanthochymus (Fruit), P. polyphylla (Rhizome), S. Chirayita (Aerial part), and A. hookeri (Aerial part) were shade dried till constant weight obtained. The coarsely powdered plant samples were extracted using 70% methanol by maceration method for 72h (24h x 3) or by Soxhlet method using methanol. The obtained filtrate was concentrated using rotary vacuum evaporator (IKA, Japan) and lyoph |
Outcome/Output: | 3 |
Organizations involved
Implementing Agency : | National Institute of Immunology, New Delhi Funding Agency :Department of Science and Technology (DBT) | Source: E-promis and Information received by Investigator | |