Cognitive Sciences and Psychology
Title : | Role of Conditioned Learning and Sleep in Adult Hippocampal Neurogenesis in the Rat |
Area of Research : | Cognitive Sciences and Psychology |
Focus Area : | Learning and memory |
Principal Investigator : | Dr. Sushil Jha, Jawaharlal Nehru University, New Delhi (110067) |
Co-PI: | Prof. Bijoy K Kunar, Jawaharlal Nehru University, New Delhi (110067) |
Contact info : | sushil_1000@yahoo.com;
bkkuanr@gmail.com |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Total Budget (INR): | 70,12,190 |
Details
Executive Summary : | Memory formation is a complex process involving acquisition, consolidation, and retrieval. Adult hippocampal neurogenesis (AHN) plays a crucial role in hippocampal-dependent memory consolidation, with increased neurogenesis enhancing learning and ablation causing memory impairment. The role of conditioned memory, such as trace-appetitive-conditioned memory, delay-appetitive-conditioned memory, and fear-conditioned memory, on AHN and its underlying mechanism is not well understood. Sleep plays a crucial role in the consolidation of conditioned memory and adult neurogenesis in the hippocampus. Short-term sleep deprivation soon after conditioning impairs the consolidation of conditioned memory, while prolonged sleep-deprivation 24 hours or more significantly alters the proliferation rate of neurogenesis in the hippocampus. It is unclear if prolonged sleep deprivation total sleep and/or REM sleep deprivation soon after conditioning appetitive conditioning and fear conditioning alters learning-induced neurogenesis in the hippocampus. Adult hippocampal neurogenesis is highly plastic and significantly modulated by hippocampal neuronal activity. Post-learning increase in newly proliferating neurons in the hippocampus and post-learning sleep play important roles in memory consolidation. Chronic sleep-deprivation immediately after learning a new task alters adult neurogenesis. Neuronal activity increases during memory acquisition and is reactivated during post-learning sleep. However, it is not known if hippocampal glutamatergic neurons involved in long-term potentiation of associative memories are reactivated during post-learning sleep. |
Equipments : | Imaging System, ELISA plate reader ( Rs.2000000.00 ) , Imaging System, ELISA plate reader ( Rs.0.00 ) , Imaging System, ELISA plate reader ( Rs.0.00 ) |
Organizations involved