ZA201209026: 6-methyl-4-phenyl-5-(phenyl or cycloalkyl)carbamoyl-1,2,3,4-tetrahydropyrimidin-2-one derivatives as antitubercular agents

The invention discloses antitubercular compounds selected from tetrahydropyrimidones/ tetrahydrothiopyrimidone derivatives of formula A and its pharmaceutically acceptable salts for the treatment of Mycobacterium in the dormant phase. Formula A wherein, R is H, halogen, dihalogen, O-alkyl, di-O-alkyl, R1 is phenyl, chlorophenyl, nitrophenyl, diclorophenyl, cycloalkyl, preferably cyclohexyl, X is O or S.