Patents

ZA201004272: An improved process for preparation of trans-3,4-diarylchroman

The invention describes an improved and advantageous process of preparation of trans 3,4-diarylchroman and similar derivatives thereof, useful as anti-fertility, anti-osteoporotic and breast cancer drugs. Condensation of arenes with 2,2-dialkyl-3-aryl chromene in the presence of a Lewis acid furnishes trans -3,4-diaryl-2,2-dialkylchroman exclusively. Thus trans-2,2-dimethyl-3-phenyl-4-(4-hydroxyphenyl) chroman, the precursor of Ormeloxifene is obtained in excellent yield by hydroarylation of phenol with 2,2-dimethyl-3-phenyl chromene.

Filing Date: 17-06-2010

Issue Date: 30-03-2011

Applicant: CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow

Patent No: ZA201004272

Application No: 2010/04272

Inventor(s): Devi Prasad Sahu

Country: South Africa

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