Patents

US9617280: Spiro-oxazines, indolinones and preparation thereof

The invention relates to novel spiro-oxazine analogs of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II further the invention provides transition-metal free Multicomponent Reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile, under mild condition leading to the formation of the desired complex of spiro-oxazine analogs (I) and indolinone analogs (II) in high yield and selectivity.

Filing Date: 12-11-2015

Issue Date: 11-04-2017

Applicant: CSIR-National Chemical Laboratory (CSIR-NCL), Pune

Patent No: US9617280

Application No: 14/890846

Inventor(s): Akkattu Thankappan Biju; Anup Bhunia; Tony Roy

Country: United States of America

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