US9580452: An antioxidant compound having anti atherosclerotic effect and preparation thereof

The invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The invention more particularly relates to the synthesis of TPP+ coupled esculetin (Mitochondria-targeted esculetin [Mitb-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-11-induced atherosclerosis in apolipoproteinE knockout (ApoE/_) mice along with the endothelial cell age-delaying effects of Mito-Esc.