US8759339: Pyrrolo[2,1-c][1,4]naphthodiazepine linked piperazine compounds and a process for the preparation thereof

The invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R'=(Formula II). n=1-9 and R''=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl.