Process for the synthesis of isonicotinic acid hydrazide

The invention provides a process for the manufacture of isonicotinic acid hydrazide(INH). INH is useful in the treatment of tuberculosis. The invention relates to the single step conversion of isonicotinamide by hydrazine hydrate to isonicotinic acid hydrazide (INH) of yield greater than 95% (w/w) and purity more than 99%.

Patent Assignee: Council of Scientific & Industrial Research (CSIR)

Patent No: US6734309 [USA]

Application No: 393372

Inventor(s): Ray, Subhash Chandra; Nandi, Lakshmi Narayan; Singh, Baldev; Prasad, Hiralal; Maharaj, Sumant; Sarkar, Prodyot Kumar; Dutta, Pashupati; Roy, Shyam Kishore; Yadav, Satya Niketan; Bandyopadhyay, Anup Kumar

Issue Date: 05-11-2004

Filing Date: 20-03-2003

Licensing Option: Laboratory willing to jointly develop technology with industrial partner.

Implementing institute: CSIR-Central Institute of Mining and Fuel Research [CSIR-CIMFR]

Funding agency: Council of Scientific and Industrial Research (CSIR)

IPC Classification: C07D 213/56

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