A process for optical resolution of racemic 1-arylethyl acetates

The present invention provides a process for the enantioselective resolution of racemic 1-arylethyl acetates with an indigenous soil microbe strain Pseudomonas fluorescens RRLJ 134 isolated from the top soil of a tea plantation of north-east India. The strain, maintained in nutrient agar slant and grown in King's B medium, was inoculated with the substrate 1-aryl acetates in succinate medium. The resolution of R/S-1-arylethyl acetate with Pseudomonas fluorescens RRLJ 134 was highly enhanced in presence of surfactant Tween-80 (0.01%) to afford S(-)-1-arylethyl acetate and R(+)-l-arylethanol in high enantiomeric excess.

Patent Assignee: Council of Scientific & Industrial Research (CSIR)

Patent No: IN223534 [India]

Application No: 474/DEL/2003

Inventor(s): Utpal Bora; Chandan Jyoti Saikia; Ashim Kumar Mishra; Dileep Kumar B S; Romesh C H Boruah

Issue Date: 26-09-2008

Filing Date: 27-03-2003

Licensing Option: Laboratory willing to jointly develop technology with industrial partner.

Implementing institute: CSIR-North East Institute of Science and Technology [CSIR-NEIST]

Funding agency: Council of Scientific and Industrial Research (CSIR)

IPC Classification: A01N 63/00

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