Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof

The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepines compounds of general formula V as shown below, which are useful as potential antitumour agents and a process of preparing these compounds; particularly the present invention provides a process for the preparation of 7-methoxy-8-{n-[7-methoxy-(11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]ben-zodiazepine-5-one-8-yloxy]alkyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one, with varying aliphatic chain length and its 2-hydroxy derivatives.

Patent Assignee: Council of Scientific & Industrial Research (CSIR)

Patent No: US6884799 [USA]

Application No: 401782

Inventor(s): Kamal, Ahmed; Ramesh, Gujjar; Srinivas, Olepu; Ramulu, Poddutoori

Issue Date: 26-04-2005

Filing Date: 31-03-2003

Licensing Option: Laboratory willing to jointly develop technology with industrial partner.

Implementing institute: CSIR-Indian Institute of Chemical Technology [CSIR-IICT]

Funding agency: Council of Scientific and Industrial Research (CSIR)

IPC Classification: C07D 487//00, A61K 031//55

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