Patents

Indolicidin analogs with anti-microbial activity

The present invention relates to three single tryptophan analogs ILPWKLPLLPLRR-amide (IL4) (SEQ ID NO: 1), ILPLKLPWLPLRR-amide (IL8) (SEQ ID NO: 2) and ILPLKLPLLPWRR-amide (IL11) (SEQ ID NO: 3), of Indolicidin, a cationic tridecapeptide amide found in the granules of bovine neutrophils. The analogs possess amino acid only at the 4th, 8th or 11th position from the N-terminal, with leucine at its all other conventional positions.The analogs selectively having only anti-microbial activity and no hemolytic activity of Indolicidin, and thereby providing therapeutic options and a method thereof.

Filing Date: 25-03-2002

Issue Date: 10-03-2006

Patent No: US7115572 [USA]

Application No: 10/106,802

Inventor(s): Subbalakshmi, Chilukuri; Bikshapathy Eruguraia; Sitaram, Narasimhaiah; Nagaraj, Ramakrishnan

Licensing Option: Laboratory willing to jointly develop technology with industrial partner.

Implementing institute: CSIR-Centre for Cellular and Molecular Biology [CSIR-CCMB]

Funding agency: Council of Scientific and Industrial Research (CSIR)

IPC Classification: A61K 38/10, C07K7/08

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