Patents
The invention relates to novel clot specific streptokinase proteins possessing altered plasminogen characteristics. The invention further relates to a process for the preparation of the said proteins. The streptokinases so produced have properties of enhanced fibrin selectivity as well as kinetics of plasminogen activation that are distinct from that of natural streptokinase in being characterized by a temporary delay, or lag, of several minutes in the initial rate of the catalytic conversion of plasminogen to plasmin (a process termed hereafter as "PG activation").