An improved process for preparation of nicotinamides

The present invention relates to an improved process for conversion of cyanopyridines to nicotinamides in the range of 0.8 to 2.0 moles in water in the range of 1.5 to 8.0 moles; add manganese dioxide catalyst prepared in neutral medium in the range of 0.01 to 0.03 moles, refluxing the reaction mixture at the temperature in the range of 100 to 115°C for a time period in the range of 6 to 15 hours, cc room temperature filtering and washing with water the resultant mixture and evaporating the filtrate to dryness to obtain the said nicotinamide.

Patent Assignee: Council of Scientific & Industrial Research (CSIR)

Patent No: IN192739 [India]

Application No: 295/DEL/2002

Inventor(s): Subhash Chandraray; Baldev Singh; Sumant Maharaj; Hiralal Prasad; Prodyot Kumar Sarkar; Pashupati Dutta; Shyam Kishore Roy; Anup Kumar Bandopadhyay; Raja Sen

Issue Date: 15-05-2004

Filing Date: 26-03-2003

Licensing Option: Laboratory willing to jointly develop technology with industrial partner.

Implementing institute: CSIR-Central Institute of Mining and Fuel Research [CSIR-CIMFR]

Funding agency: Council of Scientific and Industrial Research (CSIR)

IPC Classification: A61K 31/495

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