Research

Chemical Sciences

Title :

Visible light driven synthesis of fused O-heterocycles via radical cross coupling methodologies

Area of research :

Chemical Sciences

Principal Investigator :

Dr. Anuj Sharma, Indian Institute Of Technology (IIT) Roorkee, Uttarakhand

Timeline Start Year :

2022

Timeline End Year :

2025

Contact info :

Details

Executive Summary :

Visible light photocatalysis offers a promising avenue for organic synthesis in a mild and sustainable manner. Its applicability to cross-coupling reactions using Csp2-H, Csp3-H, and X-H bonds has been identified and is continuously evolving. However, it has its own shortfalls, such as a mediocre redox potential range of many photocatalysts, which limits its applications towards certain substrates. To mitigate these issues, new developments have emerged, such as EDA complexes driven strategies, direct HAT assisted methods, and hydrogen evolution (oxidant-free) strategies. Hydrogen evolving cross-coupling methodologies are still in their infancy, but they are expected to revolutionize the way cross-coupling will be seen in the future. Electron-donor-acceptor (EDA) complex reactions have gained interest among the scientific community, as they do not require the use of any catalyst for successful execution in the synthesis of organic compounds. In the last 3-4 years, hydrogen atom transfer (HAT) reactions have emerged as a unique approach toward C-C and C-X bonds formation through C-H functionalization. This proposal aims to bridge these aspects, focusing on the applications of EDA, HAT, and hydrogen evolution in the synthesis and functionalization of oxygenated heterocycles such as coumarins and 2-benzofuranone under visible-light-driven radical cross-couplings. The proposed methods are application-oriented and will require elaborate mechanistic studies to unravel the electronic intricacies playing underneath.

Total Budget (INR):

21,94,500

Patents :

1

Organizations involved