Executive Summary : | The current project aims to design chiral 3D discrete architectures with chiral nano-pockets for chiral recognition/separation and chemical reactions within these pockets, with a special emphasis on catalyzing enantioselective transformations. Self-assembled cages with confined spaces have gained significant attention in recent times due to their potential applications in catalysis. However, the literature is dominated with examples of achiral cages, and synthesis of chiral architectures is challenging. This proposal aims to use metal-ligand coordination as the driving force for the construction of chiral three-dimensional architectures of Pd, Pt, and Ru metals. The confined pocket of these newly designed architectures will be used to study the binding of different enantiomers, which is useful and otherwise difficult to separate. The confined pocket of some architectures will have different chiral functional groups, causing sufficient chirality within the pocket for performing enantioselective organic transformations within these molecular containers. The use of enantiopure 90 Ru(II) octahedral acceptor to generate coordination cages using propeller-shaped ligand/s for the construction of enantiopure cages will also be explored. Encapsulation of a wide variety of guest molecules will be performed, with a particular focus on luminescent molecules that undergo self-quenching of fluorescence due to aggregation. |