Executive Summary : | The synthesis of heterocycles is a growing area of chemical research, with a focus on greener methodologies using renewable starting materials. Alcohol is an economical and abundantly available greener substrate, and the transition metal-catalyzed acceptorless dehydrogenative coupling (ADC) strategy offers an environmentally benign synthesis of numerous N-heterocycles using alcohols. Nickel catalysis has shown promise as an alternative to noble metal catalysis for C-C and C-N bond formations. Different chelating pincer ligands, such as NCN, PCP, PNP, SNS, NNN, and PNN, will be synthesized and characterized. New nickel(II) complexes will be synthesized from the reaction of different pincer ligands with Ni(II) precursors in suitable solvents. The coordination of ligands to metal and the formation of the complexes will be established using analytical, spectral methods, and single crystal X-ray crystallography. The detailed studies on the formation and properties of air stable nickel(II) complexes containing different pincer ligands will provide access to a fundamental understanding of various reactions in organometallic chemistry and new applications of these complexes. The catalytic efficiency of synthesized nickel(II) pincer complexes will be explored in the green synthesis of heterocycles from alcohols and suitable amine coupling partners via acceptorless dehydrogenation coupling strategy. The formation and yields of final products will be confirmed by NMR and the percentage of conversions will be determined by GC-MS. The project aims to generate a new family of nickel(II) pincer complexes as efficient catalysts for sustainable synthesis of biologically important N-heterocyclic compounds under non-toxic conditions. |