Executive Summary : | Recent outbreak and spreading of SARS-CoV-2 is a real threat to human health. Presently 756,581,850 people are infected globally and 6,844,267 people died because of COVID-19 infection. Till today not a single drug molecule is available which can cure COVID-19 infection completely. Scientists are continuously trying to develop new molecules which can effectively inhibit the growth SARS-CoV-2 and stop the COVID-19 infection. Peoples have targeted the receptor Binding Domain (RBD), using which viral attachment to ACE2 receptors present in humans takes place. But due to rapid mutation in protein present in RBD, targeting RBD domain is not so affected. Then Mpro protease, which is essential for viral replication, is a fantastic targeting protein. A few molecules have been reported, which effectively bind with Mpro protease and stop its activities. So development of new kinds of peptidomimetic compounds which will bind with the active sites of Mpro protease by different chemistry is highly desirable. Herein, a series of peptidomimetic molecules have been proposed which will attach to the active sites of Mpro protease through the formation of disulphide bonds and thus the peptidomimetic molecules having minimal cell toxicity will have a significant inhibitory effect on the growth of SARS-CoV-2. |