Executive Summary : | The broad aim of the research proposal is the novel synthesis and functionalization of metallocarbene derived from carbonyl compounds. Carbenes are versatile synthons in organic chemistry, and their synthesis requires diazo compounds. Diazo compounds are highly explosive, toxic and need to prepare before use. To avoid this problem, this proposal aims is the diazo-free synthesis of metallocarbene. In this proposal, part-A deals with the synthesis of low-valent metallocarbenes and their functionalization for various transformations, such as cyclopropanation, X-H insertion (X= O, NR, S), and C-H insertion and heterocyclic synthesis via deoxygenative approach of carbonyl compounds. In Part-B, we proposed the generation of electrophilic siloxy metallocarbene via visible-light-induced or thermal-induced [1,2]-silyl migration of acylsilanes followed by trapping with transition-metal catalyst. Using this methodology, one can easily access various substituted 2°-alcohols in a single step via C-H insertion (sp2 and sp3), annulation, cross-coupling, Heck-type coupling, and many other transformations without using any conventional methods such as Grignard and Barbier type reactions. The present study thus aimed at providing new avenues for the metallocarbenes (derived from carbonyl compounds) in organic synthesis. The reactions developed will find widespread applications in synthesizing heteroatom-containing small molecule therapeutics, building blocks, and biologically relevant natural products. |