Executive Summary : | Early-onset scoliosis (EOS) is defined as curvature of the spine in children more than 10 degrees with onset before age 10 years. EOS led to impaired pulmonary function because of the high risk of progressive spinal deformity and thoracic constraints during a critical time of lung development. So, there is a need for a technique that corrects spine curvature without restricting the growth and development of spine in young children. There is requirement of growth friendly spinal implant system in order to provide treatment by clinician to promote unrestricted growth of the spine and thorax by controlling the spinal deformity, with the aim of promoting normal lung development and pulmonary function. There is a necessity for a guide growth system designed to operate passively outside the body to control timely expansion to meet physiological growth through the electromagnetic based control system. Sustainable and reliable instrumentation to minimize failure and revision of surgery is currently the need of the hour. To obtain this mechanical design, the biocompatibility of the implant is needed to be verified in virtual environment prior to clinical trials. For this Finite element analysis (FEA) of conceptualized instrumentation design is require to be performed in loop manner until optimum design criteria are reached. The biocompatibility can also be accessed through cell culture in the laboratory. This study will lead to a validated and verified design of growth-friendly implants to correct the spinal deformity while allowing growth of the spine and subsequently lung growth. |