Research

Engineering Sciences

Title :

Inquiry on Structural cum Mechanical stability, and Biological behavior of Innovative biomedical glasses (sodium free and calcium rich) with the potentiality to preserve Alveolar bone resorption after tooth extraction, and to induce hemostatic nature at the time of emergency- A first-aid kit

Area of research :

Engineering Sciences

Principal Investigator :

Prof. Balakumar Subramanian, University Of Madras, Chennai, Tamil Nadu

Timeline Start Year :

2023

Timeline End Year :

2026

Contact info :

Equipments :

Details

Executive Summary :

Dental issues are prevalent among almost half of the population, due to unhealthy food habits, vitamin deficiencies, and infections caused by microorganisms. Alveolar bone regeneration is a challenge, as the bone starts to degrade without a tooth found at the affected site. Periodontitis patients also suffer from periodontal ligament damage and alveolar bone loss. The treatment involves filling the affected area with biomaterial and patching up using a membrane, known as the Guided tissue regeneration surgical method. Powder form biomaterial is used for treating defects, but it causes irritation and degrades earlier. Porosity is crucial for nutrient transfer and osteoblast cell integration. Cavities preservation and blood clots after tooth extraction or accidents are important. To address this, scaffolds made of polymers and bioactive glass with specially designed properties are proposed. The bioactive glass material has good biocompatibility, antibacterial properties, and osteogenic properties, but its mechanical weakness is still a challenge. Researchers aim to develop two different bioactive medical glasses with mechanical stability, good bioactivity, and osteogenic properties. The study aims to fabricate a long-lasting scaffold with higher hemoclot and antibacterial ability, a more stable scaffold for alveolar bone and socket preservation, and a hemostat that serves as a first aid kit during emergencies. The chemistry of the bioactive glass will be elucidated, and a bioactive scaffold with a specific composition could act as an ultra-express hemostat and preserve alveolar bone.

Co-PI:

Dr. Rajashree P, University Of Madras, Chennai, Tamil Nadu-600025

Total Budget (INR):

54,87,724

Organizations involved