US8841466: Series of artemisinin derivatives and process for preparation thereof

This invention relates to the synthesis of certain novel Baylis-Hillman adducts of artemisinin-derived aldehyde 2-[10'?-deoxoartemisininyl]-ethanal. The capabilities of introduction of three functional groups into a molecule in one step using the Baylis-Hillman reaction encouraged us to synthesize some highly functionalized derivatives of artemisinin. These highly functionalised artemisinin derivatives embodied in this document are found to be active against various cancer cell-lines.