Medical Sciences

Title :

Translating the phylogenetic affinities between a plant pathogenic oomycete phytophthora infestans and a human pathogen plasmodium falciparum to reveal evolutionary convergence in virulence secretion using in-silico, proteomic and metabolomic approaches

Area of research :

Life Sciences & Biotechnology, Medical Sciences

Focus area :

Genetics, Molecular Medicine

Principal Investigator :

Dr Souvik Bhattacharjee, Associate Professor, Jawaharlal Nehru University (JNU), Delhi

Timeline Start Year :


Contact info :

Associated Programme / Scheme :

Core Research Grant (CRG)


Executive Summary :

The evolution of parasitism in eukaryotes dictates unique molecular processes for successful infection. Microbial pathogens cause disease by trafficking proteins into their cognate hosts. Secreted effectors in many bacterial species carry leader sequences that enable their transport using conserved machinery. In contrast, little is known about the virulent leaders of eukaryotic pathogens. It is also unknown if such signals are indeed shared across phylogenetically linked and economically devastating pathogens of plant and animal origins. Thus, the relationships between the main groups of plant and animal pathogens needs to be fully appreciated by respective pathologists.


Dr Saikat Bhattacharjee, Associate Professor, Regional Centre for Biotechnology, Haryana

Total Budget (INR):


Organizations involved