Executive Summary : | Catalysis (Homogeneous and heterogeneous catalysis) is placed a crucial method for constructing a wide variety C-C, C-N, C-s, C-se, C-O, C-Te, C-B etc., which is the very useful synthetic strategy to achieve a target molecule based on the molecule interest. In this proposal, catalysis methods such as (dual catalysis) Photo-redox catalytic methods merged with transition metal-catalyzed C-H bond functionalization's and sustainable photo-redox methodologies for structurally important active pharmaceutical intermediates or biologically important structural motifs via radical cross coupling reactions will be employed for synthetically, economically and environmentally viable approach for complex molecule preparation including asymmetric catalysis and drug-core molecule preparation. In the recent year's researchers focused on mild and room temperature C-H bond functionalization achieved through photo-redox catalysis. Hence, Palladium catalysis merging with Photo-redox catalysis for multiple C-H bond activation rendering Polycyclic hetero-aromatic molecules rendering Blue-emission based organic material molecules in room temperature based sustainable methodologies. The further interest towards, norbornene as a transient mediator for selective meta C-H functionalization in biaryl systems. In this regard, our interest towards C-s bond formation using transition metal and visible-light photo-redox combination with auxiliary assisted sp2 and sp3 C-H bond activation. The base transition metal catalyzed sulfenylation of sp2 C-H bonds, also Pd(II)-catalyzed highly regioselective γ-chalcogenation, thioarylation, and selenoarylation and sulfoximination of aliphatic carboxylic acids has been demonstrated via sp3 C-H bond activation was proposed. coumarin is a ubiquitous structural motif and was chosen for functionalization in a simple and sustainable methodology. Further, Blue LED mediated arylation of coumarin via in-situ radical generated from Phenylhydrazine and this simple and effective methodology opens up for the direct synthesis of coumarin-based drug molecules. subsequently, represents direct oxidative methods for sulfoximination of coumarin via C-N bond formation methods and direct oxidative methods for azolation of coumarin via C-N bond formation methods. some of the interesting drug core containing Coumarin, Quinoxlin-4-ones molecules based drug synthesis were proposed. ortho-Hydroxyaryl enaminones can act as key starting materials for the synthesis of chromone derivatives. since benzoic acids or Phenylhydrazines can undergo decarboxylative radical reactions under photochemical conditions, coupling of phenyl radical generated from benzoic acids or phenylhydrazines with the ortho-hydroxyaryl enaminones under suitable photochemical conditions can give flavone or isoflavone. |