Research
Title : | A rapid approach to generate immortalised B cells for monoclonal antibody generation from SARS-CoV-2 recovered and vaccinated group |
Area of research : | COVID-19 Research, Life Sciences & Biotechnology |
Focus area : | Monoclonal antibody generation |
Principal Investigator : | Dr TR Santhosh Kumar, Scientist, Rajiv Gandhi Centre for Biotechnology (RGCB), Kerala |
Timeline Start Year : | 2020 |
Contact info : | trsanthosh@rgcb.res.in |
Details
Executive Summary : | This study aims to identify subset of COVID-19 recovered patients and immunised volunteers with high titer neutralising antibodies for the in vitro B cell immortalisation for neutralising antibody generation. |
Outcome/Output: | The antibody response heterogeneity reported in COVID-19 infected patient and immunised population is huge. The potential utility of such repertoire of antibodies with viral neutralising activity is yet to be fully exploited for diagnostic or therapeutic purpose. This requires a high efficient approach to identify high neutralising antibody response and selection and expansion of respective B cells producing antibodies. |
Organizations involved
Implementing Agency : | Rajiv Gandhi Centre for Biotechnology (RGCB), Kerala Funding Agency :Department of Biotechnology (DBT) Govt. of India | |