Research
Title : | mRNA based vaccine for SARS-CoV-2 |
Area of research : | COVID-19 Research, Life Sciences & Biotechnology |
Focus area : | Vaccine for SARS-CoV-2 |
Principal Investigator : | Prof. Alok Srivastava, Christian Medical College (CMC), Vellore |
Timeline Start Year : | 2020 |
Contact info : | aloks@cmcvellore.ac.in |
Details
Executive Summary : | This project aims to develop an mRNA based vaccine for SARS-CoV-2. |
Outcome/Output: | Chemically modified spike mRNA was synthesised with lab designed 5’ and 3’ UTRs and validated functionally. The lyophilised mRNA-lipid nanoparticles were found to be stable at 4° C for up to a week that addresses a critical challenge in the transportation of mRNA vaccines. Promisingly vaccinated animals produced strong immune responses against spike protein and neutralised SARS-CoV-2 pseudovirus. |
Organizations involved
Implementing Agency : | Christian Medical College (CMC), Vellore Funding Agency :Department of Biotechnology (DBT) Govt. of India | |