Executive Summary :
|The SERB will support exploration of metabolomics alteration in COVID-19-infected patients conducted by IIT Bombay in collaboration with some hospitals in Mumbai. The Study will identify potential biomarker candidates to predict progression from nonsevere to severe COVID-19 conditions. Search for potential diagnostic candidates will involve metabolite profiling of different patient groups with various complications. Metabolites are small biomolecules, capable of regulating various pathways in all the living-organisms.
Dr Sanjeeva Srivastava, Professor at IIT Bombay, with the expertise of using state-of-the-art mass spectrometry-based technologies, has teamed up with Dr Om Shrivastav, Director, Infectious Diseases, Jaslok Hospital, Mumbai and Dr Jayanthi S. Shastri, Professor & Head (Microbiology), T N Medical College & Nair Hospital and Dr. Mala Vinod Kaneria, Infectious Disease Specialist at Kasturba, Nair & Jaslok Hospitals, for this research. An advanced mass spectrometry-based national facility equipped with hybrid and tribrid mass spectrometers will facilitate the analysis of nasopharyngeal swab and plasma samples. A team of over 20 researchers having expertise in handling a large number of different types of human biospecimens for proteomics and metabolomics investigations will work on it.|