Executive Summary : | The development and improvement of chemosensors for the detection and quantification of biologically and environmentally essential analytes is of extensive significance. In order to effectively use developed chemosensors, they are required to be highly sensitive and selective for a particular analyte. The synthesis method for such selective chemosensors may involve long synthetic routes so as to formulate receptor pseudo-cavity that is compatible with analyte.29 At the same time, receptor pseudocavity must be distinctive for the analyte under study and should not bind strongly, not even for closely related analytes, for example, selectivity for one metal ion from group of alkaline earth metal ions etc. Thus the present project is designed to fabricate the polymer dots and metal complexed monomers to generate polymeric network to improve the recognition properties of chemosensor and compare their sensing activity with monomeric systems. The theme of this work is based upon the idea that the monomeric receptor is expected to be very flexible that may undergo geometry change according to the steric requirement of any analyte. However, by reducing the flexibility of this receptor in some way, then the selectivity of can be improved. The one strategy could be the polymers processed into polymer dots, this may curb some of the coordination modes, and will thus result into a more selective sensor. Further, polymers/polymer dots will be processed into thin sheets for commercial applications. With synthetic skills, multicomponent tandem polymerized receptor systems will be synthesized to generate a wide range of sensors through modulating their structural features can be developed. It has been noted from the literature reports that the most of the reported sensors are able to perform in organic or semi-aqueous medium. However, the presence of organic medium in such cases may limit the use of these sensors in biologically important samples. Hence, the molecular sensors will be developed that offer advantage over literature reports and help in performing sensor studies in aqueous medium. Fluorescence spectroscopy is highly sensitive and rapid the technique that has a key role in molecular sensing. Similarly absorption spectroscopy helps in developing chromogenic systems that are effective tools for ON-SITE testing. Recently, there are several reports relating the nanotechnology with molecular sensing, for the development of ultrasensitive detection and imaging methods. We will explore the possibility for the recognition of biologically important analytes in real biological conditions. |