Life Sciences & Biotechnology
Title : | Enriching Unnatural Amino Acids (UAAs) toolkit via transition-metal catalyzed site selective functionalization/annulation of distal C(sp2)-H bonds |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Protein engineering |
Principal Investigator : | Dr Rajeev Sakhuja, Associate Professor, Birla Institute of Technology and Science (BITS), Pilani |
Timeline Start Year : | 2021 |
Contact info : | sakhuja.rajeev@gmail.com |
Associated Programme / Scheme : | Core Research Grant (CRG) |
Details
Executive Summary : | Proteins play a central role in almost every biological process, performing diversified functions in living organisms. The introduction of natural and Unnatural Amino Acids (UAAs) into proteins offers unprecedented capability for site-specific protein manipulation in living systems, and understanding their structure-function relationship. This study proposes to develop transition-metal catalyzed strategies for the distal C(sp2)–H bond functionalization on aryl/heteroaryl motifs of aromatic α-amino acids by envisaging the possibilities of distal C(sp2)–H bond activation, using appropriately stapled directing groups. In addition, annulation on the aromatic moiety in tyrosine and tryptophan would be explored. |
Total Budget (INR): | 38,12,400 |
Organizations involved
