Life Sciences & Biotechnology
Title : | Elucidating the mechanism of genome packaging and translocation in type I plant viruses |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Molecular Biology and Genetic Engineering |
Principal Investigator : | Dr. Tushar Ranjan,
Assistant professor cum Junior Scientist,
Bihar Agricultural University,
Sabour |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | mail2tusharranjan@gmail.com |
Details
Executive Summary : | Viruses use three different mechanisms for genome packaging: Type I, Type II, and III. Type I involves co-condensation of nucleic acid with viral capsid proteins, resulting in the assembly of virion particles without ATP. Type II and III are ATP dependent active packaging systems, operating in viruses larger than 20kb. However, little is known about the mechanism of genome packaging in smaller plant viruses. Recent discoveries suggest that capsid proteins with ATPase activity in many plant viruses have a significant role in genome packaging. The molecular machinery encapsidating genome encapsidation in plant viruses remains to be discovered and understood. A strategy to target virus assembly by mutating the ATPase domain of capsid proteins is also being developed. |
Co-PI: | Dr. Ravi Ranjan Kumar, Bihar Agricultural University, Dr. Mohammad Ansar,Bihar Agricultural University |
Total Budget (INR): | 47,76,832 |
Organizations involved
