Research

Life Sciences & Biotechnology

Title :

Discovery of structure-based antivirals against SARS-CoV-2 targeting key viral genome replication enzymes

Area of research :

COVID-19 Research, Life Sciences & Biotechnology

Focus area :

COVID-19 Therapeutics

Principal Investigator :

Prof Pravindra Kumar, Indian Institute of Technology (IIT) Roorkee

Timeline Start Year :

2020

Contact info :

Details

Executive Summary :

The project proposes to use structure-based screening of antivirals against SARS- CoV-2 targeting key viral genome replication enzymes such as viral protease that are responsible for the cleavage of non-structural polyprotein and their activation; RNA dependent RNA polymerse as it carries out both primer-independent and primer-dependent synthesis of viral RNA; and G-N7-MTase (nsp14) responsible for camouflaging and obscuring viral RNA from host cell sensing machinery.

Organizations involved