Life Sciences & Biotechnology
Title : | Development of a tumor-microenvironment responsive, cancer theranostic nanodots for photodynamic-immunotherapy |
Area of research : | Life Sciences & Biotechnology |
Focus area : | pharmaceuticals, Immunology |
Principal Investigator : | Dr. Aniruddha Roy, Associate Professor,Birla Institute of Technology and Science, Pilani |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | aniruddha.roy@pilani.bits-pilani.ac.in |
Details
Executive Summary : | The current anticancer therapies primarily target cancer cells, but they are often ineffective in most cases. Cancer is a multi-cellular disorder, and combining two or more treatment modalities can be highly beneficial. A new approach, cyclometalated iridium(III)-based Aggregation Induced Emission (AIE)-active near infra-red (NIR) emissive PS (AIEgen), is proposed for better PDT therapy. This would enable deep penetration of light for photo-activation and overcome drawbacks like aggregation-caused quenching (ACQ). The next generation AIE-based PS could pave the way for simultaneous therapy and diagnosis applications. Combining photodynamic-immunotherapy with AIEgens and a TLR7+8 agonist R848 could significantly improve current treatment strategies. |
Co-PI: | Prof. Inamur R. Laskar, Birla Institute of Technology and Science, Pilani |
Total Budget (INR): | 49,08,856 |
Organizations involved
