Research

COVID-19 Research

Title :

Development of host-directed anti-coronavirus agents

Area of research :

COVID-19 Research, Life Sciences & Biotechnology

Focus area :

COVID-19 Therapeutics

Principal Investigator :

Dr Naveen Kumar, Scientist, National Research Centre on Equines (NRCE), Haryana

Timeline Start Year :

2020

Timeline End Year :

2020

Contact info :

Details

Executive Summary :

This study aims to screen the entire library of small molecule chemical inhibitors for their antiviral action against coronavirus-infectious bronchitis virus (IBV, a poultry virus).

Publications :

 
3

Outcome/Output:

Emetine was found to be a low nanomolar (nM) inhibitor against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) besides exhibited protective efficacy against lethal challenge with infectious bronchitis virus (IBV; a chicken coronavirus). Emetine treatment led to a decrease in viral RNA and protein synthesis. In a chromatin immunoprecipitation (CHIP) assay, emetine was shown to disrupt the binding of SARS-CoV-2 mRNA with eIF4E, a cellular cap-binding protein required for initiation of protein translation.

Organizations involved