Executive Summary : | To develop different NCHs using chitosan, CMC, HEC and PVA, linseed oil based polyol and CNT, NaMMT, fumed silica via solution blending and free radical polymerisation technique and to use the prepared NCHs as a potential candidate for their application in delivery of anticancer drug. The polyol derived linseed oil and various Nano fillers was used to prepare highly cross linked networks nanocomposite hydrogels for enhancing and distinguishing their useful properties. Nanofillers seems to dominantly affect the characteristic features like mechanical. strength, swelling, biodegradable, biocompatible and drug release behavior of nanocomposite hydrogels. The biocompatibility, cytotoxicity and drug delivery system of the resultant hydrogels were evaluated using MTT assays of normal HEK293, cell lines. The in-vitro anti-proliferative efficiency of drug loaded hydrogels for were also tested using human breast MCF-7 and colon HCT116 cancer cell lines. These studies shows that the nanocomposite hydrogels holds potential as a sustained delivery of chemotherapeutic drugs. The in vitro drug loading and release studies of anticancer drug cisplatin from the nanocomposite hydrogels have been investigated. |
