Executive Summary : | Carcinogenesis can be processed by introducing negative charge on the cell surface which arises because of glycolysis process. There are altered cell polarity and electrical surface properties of cancerous cell in comparison to normal cells. The cells become more electronegative duringthe course of carcinogenesis and the polarity of the cells changes. Change in cell membrane electrical charges alters the cell membrane stability, permeability and cell polarity. The charges available on the cell is considered as a very important parameter and may affects the other cell.It depends on various parameter like physicochemical properties and many more[4]. However, these cells are located in a crucial medium and impossible to control. Moreover, the surface charge may deviate to the initial one which may be the possible region of tumor development.The bio-impedance measurement through advance techniques may provide a new scope for the estimation ofpsychological changes in biological tissues. The genesis of the electrical characterization comes into existence in 1940’s when Kenneth Cole has introduced apotent electrical network for theimpedance measurement for biological tissues . This Cole impedance model has a capability toapproximate the human tissue which consists of a resistors (R_∞),(R_i), and a fractional capacitor (C_i).This proposal will bring an estimation of the surface properties alteration of OSCC cells under strict control. This study will investigate the essential step prior to determining what mechanisms allow us to modify or inhibit the surface charge and polarity of the OSCC cells, thus enabling intervention in the tumor development process. By physical investigation of tissue will provide the fruitful estimation before the treatment. |
Co-PI: | Dr. Mamata Maisnam, National Institute Of Technology (NIT) Manipur-795004, Dr. Sumita Banerjee, Regional Institute Of Medical Sciences, Imphal, Manipur-795004, Dr. Saikat Mukherjee, Manipur University-795003 |