Research
Title : | Incorporation of crtRB1 allele into sweet corn inbreeds and north eastern land races for development of bio-fortified sweet corn (E28AHE) |
Area of Research : | Agricultural Sciences |
Focus Area : | Biofortification, Plant Biotechnology |
Principal Investigator : | Prof. Swarup Roy, Sikkim University, Gangtok, Sikkim |
Co-PI: | Prof. Amit Chakrobarty, Sikkim University, Gangtok, Sikkim |
Contact info : | sroy01@cus.ac.in |
Timeline Start Year : | 2025 |
Timeline End Year : | 2028 |
Total Budget (INR): | 4,59,828 |
Details
Executive Summary : | Aligning PPI networks (PIN) of evolutionally related species enable to discover conserved PINs and sub-network modules/motifs. Very few methods are available for the simultaneous alignment of more than two PINs. Available methods are computationally expensive and do not guarantee optimal alignments in a single processor system. We propose to leverage Graph Neural Network (GNN) based framework to align multiple PINs. We propose to use the newly developed tool on many host-hepatotropic PINs to detect common sub-PINs representative of core host functions commonly targeted by pathogens. In the case of host-hepatotropic PINs, such conserved core components may relate to basic liver functions commonly targeted by multiple viruses. Hence, their discovery and analyses may enable us to design more effective therapeutic multi-viral drug targets. An effort will be made to prioritize suitable hepatotropic anti-viral drug targets. |
Equipments : | NA |
Outcome/Output: | 1 |
Organizations involved
Implementing Agency : | Sikkim University, Gangtok, Sikkim Funding Agency :Department of Science and Technology (DBT) | Source: E-promis and Information received by Investigator | |