Executive Summary : | The project aims to identify a composite quantitative Electroencephalography (EEG) and speech neural biomarker for detecting different psychotic disorders and planning effective treatment strategies. The study will include subjects from five groups: healthy, individuals suffering from schizophrenia, manic psychosis, depression psychosis, and substance induced psychosis. The researchers will use features from multiple modalities and clinical attributes to determine the most relevant neural biomarkers for categorizing these groups. The project will be jointly executed by NIT Raipur, AIIMS Raipur, and AIIMS Bibinagar. Psychiatric disorders like schizophrenia, bipolar disorder, and substance induced disorder lack objective clinical tests and have not been studied using combined EEG and speech neural markers to differentiate them. Quantitative EEG and speech signal analysis can play a crucial role in identifying potential neural biomarkers for automatically classifying individuals suffering from different psychotic disorders. The researchers aim to develop automated prediction of different psychotic disorders by analyzing subtle disturbances in speech and EEG signals, improving prediction performance. They will include speech modality due to its inexpensive and non-invasive nature. The hypotheses include identifying quantitative features in speech and EEG signals as neural biomarkers for diagnosing schizophrenia, manic psychosis, depression psychosis, and substance induced psychosis, demonstrating a significant correlation between speech/EEG measures and clinical ratings of different psychotic disorders, developing predictive machine learning techniques to automatically classify individuals suffering from different psychotic disorders and healthy individuals based on identified neural biomarkers, and validating the model with existing clinical identification methods. |
Co-PI: | Dr. SaiKrishna Tikka, All India Institute Of Medical Sciences (AIIMS), Bibinagar, Hyderabad, Telangana-508126, Dr. Lokesh Kumar Singh, All India Institute Of Medical Sciences (AIIMS) Raipur, Chhattisgarh-492099 |