Executive Summary : | Cardiovascular diseases (CVDs) are a major global health concern, causing lipid peroxidation, DNA damage, and protein oxidation. Angiotensin-II is linked to ROS production in cardiomyocytes, hypertrophy, and remodeling. Despite available pharmacological interventions, no undying treatment is available for myocardial infarction. This proposal explores therapeutic interventions against CVD, focusing on myocardial infarction. The study will use modern analytical tools to detect active components of medicinal plants, specifically Phlogacanthus thyrsiformis and Phlogacanthus curviflorus, traditionally used in the Assam region. The study aims to identify bioactive compounds, identify and characterize them, and evaluate their potential cardioprotective effects using an in vivo experimental cardioprotective model in rats. |