Executive Summary : | Recent evidence suggests that cancer cells adopt a "lipolytic phenotype" due to their reliance on the Fatty acid Oxidation (FAO) pathway for energy, survival, and proliferation during metabolic stress. This phenotype is also linked to drug resistance, metastatic progression, and immune suppression. Cancer cells from adipocyte-rich environments, such as breast and ovarian, are more likely to adopt this phenotype. The peroxisome, a key site for FAO, engages using substrates like very long-chain fatty acids and branched-chain fatty acids. Targeting peroxisomal FAO could help develop novel therapies, such as targeting tamoxifen resistance in breast cancer cells and overcoming tamoxifen resistance in other cancer types. |