Research
Title : | Elucidating the mechanism of genome packaging and translocation in type I plant viruses |
Area of Research : | Agricultural Sciences |
Focus Area : | Plant Biology, Agricultural Sciences, Molecular Biology |
Principal Investigator : | Dr. Tushar Ranjan,Assistant professor cum Junior Scientist,Molecular Biology and Genetic Engineering |
Co-PI: | Dr. Ravi Ranjan Kumar, Bihar Agricultural University, Bihar, Dr. Mohammad Ansar, Bihar Agricultural University,, Bihar |
Contact info : | mail2tusharranjan@gmail.com |
Timeline Start Year : | 2023 |
Timeline End Year : | 2024 |
Total Budget (INR): | 47,76,832 |
Details
Executive Summary : | Genome packaging is a crucial step in viral maturation, with three mechanisms proposed: Type I, Type II, and III. Type I involves co-condensation of nucleic acid with viral capsid proteins, resulting in the assembly of virion particles without ATP. Type II and III are ATP dependent active packaging systems, operating in viruses larger than 20kb. However, little is known about the mechanism of genome packaging in smaller plant viruses. Recent discoveries suggest that capsid proteins with ATPase activity in many plant viruses have a role in genome packaging. The molecular machinery encapsidation in plant viruses remains to be discovered and understood. A strategy to target the virus assembly process by mutating the ATPase domain of capsid proteins is also being developed. |
Organizations involved
Funding Agency : | https://bausabour.ac.in/ |