Life Sciences & Biotechnology
Title : | Multifaceted therapy for cardiac regeneration post infarction through delivery of nucleic acids and bioactives via targeted nanocarriers |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Molecular Biology, Nanobioscience |
Principal Investigator : | Dr. Virendra Gajbhiye,
Scientist E,
Agharkar Research Institute, Maharashtra |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | thejaswinivenkatesh5@gmail.com |
Details
Executive Summary : | Myocardial Infarction (MI) is the leading cause of death in cardiovascular diseases, causing cardiac cell death, loss of functionality, damaged blood vessels, and inflammation. Current treatments are temporary and cannot influence cellular processes like apoptosis, proliferation, inflammation, and vascularization. A multifaceted therapy, including gene therapy, is needed to address MI. MiRNAs play a role in cardiovascular development and disease, but clinical translation is challenging due to multiple target genes and low uptake. Recently, nanoparticles (NPs) have been synthesized to prevent hypoxia/reperfusion-induced apoptosis and induce proliferation. |
Co-PI: | Dr. Dhananjay Bodas, Agharkar Research Institute |
Total Budget (INR): | 59,00,990 |
Organizations involved
