Life Sciences & Biotechnology
Title : | Deciphering how RICTOR/TORC2 regulates one-carbon metabolism to modulate longevity depending on diet containing different Vitamin B12 content |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Molecular Biology, Immunology |
Principal Investigator : | Dr. Arnab Mukhopadhyay,
Staff Scientist VI,
National Institute of Immunology, Jawaharlal Nehru University, Delhi |
Timeline Start Year : | 2023 |
Timeline End Year : | 2025 |
Contact info : | arnab@nii.ac.in |
Details
Executive Summary : | The study focuses on the gut microbial system in worms, examining diet-gene pairs and metabolites like Vitamin B12 and Folate. The flr-4 gene mutant showed an increase in life span on HT115 but not on OP50, activating p38 MAPK signaling and cytoprotective programs. Vitamin B12 content in the bacteria activates the one-carbon cycle, leading to lower phosphatidylcholine levels. The conserved RICTOR/TORC2 complex also interacts with the flr-4 mutant, rescuing it from shorter life span on OP50 bacteria. The project aims to determine the mechanisms of RICTOR/TORC2 regulation. |
Co-PI: | Dr. Soumen Basak,
National Institute of Immunology, Delhi |
Total Budget (INR): | 68,72,992 |
Organizations involved
