Life Sciences & Biotechnology

Title :

Exploring the molecular insights and the role of mitochondrial changes during myocardial ischemia reperfusion injury and its recovery protocol in an experimental model of rat exposed to diesel particulate matter

Area of research :

Life Sciences & Biotechnology

Focus area :


Principal Investigator :

Dr Gino A Kurian, Associate Professor, SASTRA Deemed to be University, Tamil Nadu

Timeline Start Year :


Contact info :

Associated Programme / Scheme :

Core Research Grant (CRG)


Executive Summary :

Exposure to ambient air pollution is an underappreciated risk factor but increases morbidity and mortality, and is a leading contributor to the global ischemic heart disease burden. Myocardial damages due to ischemia-reperfusion (I/R), often encountered in surgical revascularisation procedures are recognised to be the result of a complex interplay between genetic and environmental factors like air pollutants. This study aims to answer the following questions: 1. Whether diesel particulate matter (representative of heavy-duty and automobile diesel engines) adversely affects the recovery of rat hearts from ischemia-reperfusion injury. 2. Whether DPM-mediated mitochondrial functional changes are similar in the subpopulation and have any consequential impact on the recovery of the heart from ischemia-reperfusion. 3. Negative influence of DPM on the cardio-protective protocol in the management of ischemia-reperfusion injury.

Total Budget (INR):


Organizations involved