Life Sciences & Biotechnology
Title : | Exploring the molecular insights and the role of mitochondrial changes during myocardial ischemia reperfusion injury and its recovery protocol in an experimental model of rat exposed to diesel particulate matter |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Pathophysiology |
Principal Investigator : | Dr Gino A Kurian, Associate Professor, SASTRA Deemed to be University, Tamil Nadu |
Timeline Start Year : | 2022 |
Contact info : | ginokurian@hotmail.com |
Associated Programme / Scheme : | Core Research Grant (CRG) |
Details
Executive Summary : | Exposure to ambient air pollution is an underappreciated risk factor but increases morbidity and mortality, and is a leading contributor to the global ischemic heart disease burden. Myocardial damages due to ischemia-reperfusion (I/R), often encountered in surgical revascularisation procedures are recognised to be the result of a complex interplay between genetic and environmental factors like air pollutants. This study aims to answer the following questions:
1. Whether diesel particulate matter (representative of heavy-duty and automobile diesel engines) adversely affects the recovery of rat hearts from ischemia-reperfusion injury.
2. Whether DPM-mediated mitochondrial functional changes are similar in the subpopulation and have any consequential impact on the recovery of the heart from ischemia-reperfusion.
3. Negative influence of DPM on the cardio-protective protocol in the management of ischemia-reperfusion injury. |
Total Budget (INR): | 47,03,600 |
Organizations involved
