Research
Title : | Molecular regulators associated with the maintenance of human trabecular meshwork stem cells in relation to their reduction in ageing and glaucoma |
Area of research : | Medical Sciences |
Focus area : | Immunology, Stem Cell Biology |
Principal Investigator : | Dr GowriPriya Chidambaranathan, Scientist, Aravind Medical Research Foundation (AMRF), Tamil Nadu |
Timeline Start Year : | 2021 |
Contact info : | gowri@aravind.org |
Associated Programme / Scheme : | Core Research Grant (CRG) |
Details
Executive Summary : | Glaucoma is a leading cause of blindness worldwide with Primary Open Angle Glaucoma (POAG) as the predominant form. It has been suggested that the age and disease-related decrease of Trabecular Meshwork (TM) cells, abnormal accumulation of ECM materials, and the appearance of the cross-linked actin networks in the TM cells contribute to an increased resistance of the AH outflow and subsequent increase of Intraocular Pressure (IOP). Recently confirmed the presence of stem cells in native TM cells by two parameter analysis–high expression of ABCG2 with high N/C ratio. |
Co-PI: | Dr Muthukkaruppan Veerappan, Professor, Aravind Medical Research Foundation (AMRF), Tamil Nadu, Dr Krishnadas SubbaiahRamaswamy, Scientist, Aravind Medical Research Foundation (AMRF), Tamil Nadu, Dr Bharanidharan Devarajan, Scientist, Aravind Medical Research Foundation (AMRF), Tamil Nadu |
Total Budget (INR): | 49,01,240 |
Organizations involved
Implementing Agency : | Aravind Medical Research Foundation (AMRF), Tamil Nadu Funding Agency :Science and Engineering Research Board (SERB), Department of Science and Technology (DST) | |