Life Sciences & Biotechnology
Title : | Understanding the role of liver-secreted Cysteine-Rich with EGF-like Domains 2 (CRELD2) in diabesity |
Area of Research : | Life Sciences & Biotechnology |
Focus Area : | Immunology |
Principal Investigator : | Dr Devram Sampat Ghorpade, Scientist, National Institute of Immunology (NII), Delhi |
Contact info : | dev@nii.ac.in |
Timeline Start Year : | 2022 |
Associated Programme / Scheme : | Core Research Grant (CRG) |
Total Budget (INR): | 61,22,360 |
Details
Executive Summary : | Diabesity is a health condition used to describe the incidences of diabetes associated with obesity. Diabesity is a major health concern and is a risk factor for the development of the disease comorbidities like cardiovascular diseases, inflammatory bowel diseases, cancers, fatty liver diseases, kidney diseases, etc. This study aims at: (1) Identification of CRELD2 expression pattern in the livers obtained from multiple models of diabesity, (2) Evaluation of the role of hepatic CRELD2 as a metabolic regulator, (3) Delineation of CRELD2-dependant molecular pathways leading to diabesity, and (4) Identification of the human relevance to the study. |
Organizations involved