Life Sciences & Biotechnology
Title : | Understanding the mechanism of hemoglobin receptor recycling by Rab GTPases in Leishmania donovani |
Area of Research : | Life Sciences & Biotechnology |
Principal Investigator : | Prof. Amitabha Mukhopadhyay, Professor, Indian Institute of Technology Delhi (IITD), Delhi |
Co-PI: | Dr C S Dey, Professor, Indian Institute of Technology Delhi (IITD), Delhi |
Contact info : | amitabha@bioschool.iitd.ac.in |
Timeline Start Year : | 2022 |
Associated Programme / Scheme : | Core Research Grant (CRG) |
Total Budget (INR): | 60,25,430 |
Details
Executive Summary : | In this study, investigators will clone and express Rab11 and Rab4 homologs from the Leishmania and try to identify their effectors. Finally, studies will be carried out to understand the role of Rab4 and Rab11 in Hb-receptor recycling pathway in Leishmania using Rab4 or Rab11 knock out parasites or parasites overexpressing dominant negative mutants of Rab4 or Rab11. |
Organizations involved